Question.3595 - Question: 1) Compare the chemical structure of amphetamine (which is the main component in all legal prescription stimulants, such as Vyvanse, Adderall, etc.) to methamphetamine on p. 151 of the text; note that the only difference is a methyl group, which allows for amphetamine to pass the blood-brain barrier faster than if it weren't methylated (i.e., methamphetamine). What are your reactions to this tiny difference in chemical structure? We have talked about dosing and frequency as being extremely important variables for determining a particular drug's action. How would these variables apply here with amphetamine/d-amphetamine and methamphetamine?
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Question: 1) Compare the chemical structure of amphetamine (which is the main component in all legal prescription stimulants, such as Vyvanse, Adderall, etc.) to methamphetamine on p. 151 of the text; note that the only difference is a methyl group, which allows for amphetamine to pass the blood-brain barrier faster than if it weren't methylated (i.e., methamphetamine).? What are your reactions to this tiny difference in chemical structure?? We have talked about dosing and frequency as being extremely important variables for determining a particular drug's action.? How would these variables apply here with amphetamine/d-amphetamine and methamphetamine? By a single methyl group, the chemical structures of amphetamine and methamphetamine differ. This small change can significantly impact their pharmacological effects, especially how fast they can cross the blood-brain barrier. Methamphetamine is more lipophilic due to this methylation; it penetrates the brain faster than amphetamine, potentially leading to heightened effects and a greater risk of addiction. When dosing and frequency are considered, these factors play an important role in determining the drugs' actions. Amphetamine is prescribed for controlling doses to manage conditions like ADHD, while methamphetamine's illicit use often comes with higher doses and involves more frequent consumption, which increases the likelihood of adverse effects and dependency. This stark contrast addresses the importance of regulation in therapeutic contexts versus recreational use.More Articles From Others
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